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. 2023 Sep 28;114(12):4571–4582. doi: 10.1111/cas.15980

FIGURE 1.

FIGURE 1

Pancreatic neuroendocrine neoplasm (panNEN) shows high expression of autotaxin (ATX). (A) Serum ATX level in panNEN, intraductal papillary mucinous neoplasm (IPMN), pancreatic ductal adenocarcinoma (PDAC), chronic pancreatitis (CP) and healthy control by sex. The number of patients with each pathology was: in males, panNEN in 7, IPMN in 5, PDAC in 30, CP in 26, with 16 healthy controls; in females, panNEN in 7, IPMN in 9, PDAC in 32, CP in 3, with 10 healthy controls. Bars, standard error; *p < 0.05, **p < 0.01. (B) Representative images of immunohistochemical staining for ATX expression in panNEN. Insets show magnified views of boxed areas. Magnification: ×40; inset ×200. Case 1 was a patient with panNET G2, and case 2 involved neuroendocrine carcinoma. Bottom: normal pancreatic duct from the same slide in case 1. (C) Relative mRNA expression of ATX in AsPC‐1 (n = 3), Capan‐2 (n = 4), QGP‐1 (n = 4), and BON‐1 (n = 3). Bars, standard error.