Table 3.
Variation of fraction of tumor-infiltrating immune cells under afatinib according to metabolic response on FDG-PET scan by PERCIST.
| Immune cells | Non-responders (N = 11) | Responders (N = 15) | Ratio of median | P-value | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Median¶ | Min | Max | Median¶ | Min | Max | |||||
| B cells | 0.8 | 0.3 | 5.3 | 1.8 | 0.9 | 5.9 | 2.1 | 0.02 | ||
| Macrophages | 1.6 | 0.7 | 3.3 | 1.1 | 0.6 | 5.4 | 0.7 | 0.2 (NS) | ||
| Monocytes | 0 | −0.01 | 0.03 | 0 | 0 | 0.09 | – | 0.2 (NS) | ||
| Neutrophils | −0.005 | −0.03 | 0.1 | −0.007 | −0.05 | 0.02 | 1.4 | 0.6 (NS) | ||
| NK cells | 1.4 | 0.3 | 2.5 | 1.3 | 0 | 3 | 0.9 | 0.9 (NS) | ||
| T cells CD4+ | 1.4 | 0.2 | 5.8 | 1.4 | 0.4 | 9.5 | 1.1 | 0.6 (NS) | ||
| T cells CD8+ | 0.003 | −0.004 | 0.03 | 0 | −0.05 | 0.2 | 0 | 0.4 (NS) | ||
| Uncharacterized cells$ | 0.9 | 0.7 | 1.3 | 0.9 | 0.5 | 1.2 | 1.1 | 0.6 (NS) | ||
NS not significant.
$Uncharacterized cells are representative of cells outside immune subtypes, including tumor cells.
¶Median post-afatinib/pre-afatinib fractions were computed in B cells, macrophages, NK cells, T cells CD4+ and CD8+, and uncharacterized cells; median immune cell fractions derived by subtracting the post-afatinib cell fraction from the pre-afatinib cell fraction were computed in monocytes, neutrophils, and T cells CD8+.
Significant values are in bold.