Fig. 5. Male mice treated with B. fragilis display dysregulated social novelty behavior.

Behavioral analysis of eight-week-old B. fragilis-treated mice in three chamber social behavior paradigm. Representative picture created with biorender.com. a Preference of male mice for sniffing an empty chamber or chamber with a novel mouse. Calculated as social index. b Preference of male mice for sniffing a chamber with familiar mouse or novel mouse. Calculated as social novelty index. c Preference of female mice for sniffing an empty chamber or chamber with novel mouse. Calculated as social index. d Preference of female mice for sniffing chamber with familiar mouse or novel mouse. Calculated as social novelty index. Two tailed paired student’s t-test **=p < 0.01 ***=p < 0.001 n = 11 per group. Error bars represent standard error of the mean.