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. 2023 Dec 18;9:103. doi: 10.1038/s41522-023-00469-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Volcano plot of genes in differential expression analysis between B. fragilis treated and untreated mice. X axis is log fold change of genes between treatment groups and Y axis is negative log p value of each gene. b–e GSEA analysis describing enriched gene categories among upregulated or downregulated genes. b Enrichment of cholesterol biosynthesis genes in B. fragilis-treated group and c a decrease of genes related to neural crest differentiation in the same treatment group. d A decrease in genes expressed specifically in inhibitory interneurons in the B. fragilis-treated group together with a decrease in e inhibitory interneuron progenitor genes in the same group.