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. 2023 Dec 18;14:8396. doi: 10.1038/s41467-023-44203-0

Fig. 6. KAT5 promotes NLRP3 inflammasome activation in vivo.

Fig. 6

ae Kat5fl/fl or Kat5fl/flLyz2-Cre male mice of 6–8 weeks were injected with Saline (n = 3 biologically independent mice) or LPS (20 mg/kg, i.p.) (n = 7 biologically independent mice) for 12 h. a, b ELISA analysis of IL-1β (p:3.65*10−9) and TNF-α in serum. c representative H&E images of lung sections Scale bar = 100 μm. d lung injury score(p:7.28*10−5). e Immunoblot analysis of IL-1β and caspase-1 from lung of Kat5fl/fl or Kat5fl/flLyz2-Cre mice. casp-1(caspase-1) (f, g) Kat5fl/fl or Kat5fl/flLyz2-Cre male mice of 6–8 weeks were injected with Saline (n = 3 biologically independent mice) or MSU (1 mg, i.p.) (n = 7 biologically independent mice) for 8 h. ELISA analysis of IL-1β(p:5.49*10−7) and quantification of peritoneal exudate neutrophil cells in the peritoneal cavity fluid. Results are represented as mean ± SD. Statistical analyses were carried out via two-way ANOVA with the Bonferroni test for (a, b–d–f, g). Source data are provided as a Source Data file.