Skip to main content
. 2023 Dec 18;14:8396. doi: 10.1038/s41467-023-44203-0

Fig. 7. KAT5 inhibitor-NU 9056 suppresses NLRP3 inflammasome in vivo.

Fig. 7

a–e Wild-type C57BL/6 J male mice of 6-8 weeks were injected with Saline or NU 9056 (5 or 10 mg/kg) 30 min followed with injection of Saline (n = 3 biologically independent mice) or LPS (20 mg/kg, i.p.) (n = 5 biologically independent mice) for 12 h. a, b ELISA analysis of serum IL-1β (Saline group VS NU 9056 group p:9.4*10−6) and TNF-α. c representative H&E images of lung sections. Scale bar = 100 μm. d lung injury score. e Immunoblot analysis of IL-1β and caspase-1 from lung. casp-1 (caspase-1) (f, g) Wild-type C57BL/6 J male mice of 6–8 weeks were injected with Saline or NU 9056 (10 mg/kg) 30 min followed with injection of Saline (n = 3 biologically independent mice) or MSU (1 mg, i.p.) (n = 7 biologically independent mice) for 8 h. ELISA analysis of IL-1β (p:3.88*10−8) and quantification of peritoneal exudate neutrophil cells (p:4.75*10−5) in the peritoneal cavity fluid. Results are represented as mean ± SD. Statistical analyses were carried out via two-way ANOVA with the Bonferroni test for (a, b, d, f, g) Source data are provided as a Source Data file.