Table 1.

Linear mixed effects models depicting associations between general cognition and fronto-parietal PFN topography

	PFN 3				PFN 15				PFN 17
Predictors	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf	β	Std. Error	t	pbonf
Discovery
Intercept	0.02	0.02	0.69	0.488	0.07	0.02	2.95	0.003	−0.04	0.02	−1.52	0.128
Age	−0.04	0.02	−2.54	0.011	−0.02	0.02	−1.28	0.201	−0.04	0.02	−2.58	0.010
Sex	−0.05	0.03	−1.60	0.109	−0.15	0.03	−4.51	6.72 x 10−6	0.05	0.03	1.57	0.117
Mean FD	0.12	0.02	6.98	3.44 × 10−12	0.12	0.02	6.82	1.06 x 10−11	0.04	0.02	2.22	0.027
General Cognition	0.08	0.02	3.24	0.001	0.09	0.02	3.50	4.67 x 10−4	0.10	0.02	4.29	1.88 x 10−5
Replication
Intercept	0.01	0.02	0.43	0.665	0.07	0.02	2.82	0.005	−0.02	0.02	−1.00	0.320
Age	−0.01	0.02	−0.84	0.400	−0.06	0.02	−3.32	9.02 x 10−4	−0.05	0.02	−2.65	0.008
Sex	−0.04	0.03	−1.28	0.199	−0.15	0.03	−4.27	2.01 x 10−5	0.04	0.03	1.11	0.265
Mean FD	0.16	0.02	9.05	2.39 x 10−19	0.08	0.02	4.54	5.81 x 10−6	0.04	0.02	2.11	0.035
General Cognition	0.08	0.02	3.07	0.002	0.09	0.02	3.74	1.84 x 10−4	0.12	0.02	4.68	2.98 x 10−6

Note that data were harmonized across sites using ComBat^58,59 and each model also included a random effect term for family ID. Bold font indicates statistically significant p-values (p < 0.05) after Bonferroni correction for multiple comparisons