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. 2023 Dec 5;14:1280884. doi: 10.3389/fimmu.2023.1280884

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Copyright © 2023 Rowe, Nwaolu, Salinas, Hong, Nunez, Lansford, McCarthy, Potter, Levi and Davis

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAK2 inhibition mitigates trauma-induced heterotopic ossification (HO) formation. Micro-computed tomography scans were performed on vehicle- and PF573228-treated rats following sequential polysystem injury at week 8. (A) Total new bone was determined using Dragonfly software to identify the difference between new bone (green) and naïve bone (grey). (B) Quantitative measure of ectopic bone volume. Unpaired t-test analyses revealed a trend (p=0.0785) towards a reduced formation of ectopic bone at the amputation site in the PF573228-treated injured rats (n=5; 10 mg/kg/day; 6.94 µg/kg/min for 14 days) compared to the vehicle-treated injured rats (n=5). Data presented as mean values ± SEM. ^# indicates a large effect size (GΔ = 1.05).