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. 2023 Dec 5;14:1276038. doi: 10.3389/fphar.2023.1276038

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Copyright © 2023 Ye, Liu, Song, Gao, Fang, Hu, Zhang, Liao, Cui and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects and mechanism of Salvia miltiorrhiza and its effective ingredients on bone metabolism. Note: NO, Nitric Oxide; BMP, bone morphogenetic protein; Nox4, NADPH Oxidase 4; ALP, alkaline phosphatase; Runx2, Runt-related transcription factor 2; OCN, Ostecalcin; TRAP, Tartrate resistant acid phosphatase; RANKL, Receptor activator of nuclear factor kappa-Β ligand; OPG, Osteoprotegerin; MSC, mesenchymal stem cells; JNK, c-Jun-N-terminal-kinase; ERK, Extracellular regulated protein kinases; NF-κB, Nuclear factor kappa-B; NFATc, Nuclear Factor Of Activated T Cells; HSC, Hemapietic stem cell.