TABLE 2.
Summary of commercial drugs of Salvia miltiorrhiza and its active ingredients.
| Drug name | Dosage form | Ingredients | Time of approval and regulator | Treatment indications | Mechanisms |
|---|---|---|---|---|---|
| Tanshinone IIA sodium sulfonate injection | Injections | Tanshinone IIA sodium sulfonate | 2002 (NMPA, China) | Used for coronary artery disease, angina pectoris, myocardial infarction, and also used for premature ventricular beats | Increase coronary flow and improve ischemic areas cardiac muscle of lateral circulation and local blood supply, improve myocardial metabolic disorders, increase myocardial resistance to hypoxia, inhibit Platelets aggregation and anti-thrombus formation, reduce the area of ischemic myocardial infarction in experimental animals, and enhance myocardial contractility at certain doses |
| Salvia polyphenolic acid salt for injection | Injections | Salvia polyphenolic acid salt | 2011 (NMPA, China) | For stable angina pectoris in coronary artery disease, graded as grade I or II, with mild to moderate angina pectoris symptoms and TCM evidence of heart blood stasis, with symptoms of chest pain, chest tightness, palpitations | Promoting blood circulation, resolving blood stasis and clearing blood vessels |
| Tanshinone Capsules | Capsules | Salvia miltiorrhiza ethanol extract (cryptotanshinone, tanshinone I, tanshinone IIA, tanshinone IIB, methyl tanshinolate, hydroxytanshinone IIA, dihydrotanshinone I, tanshinxinkun A, tanshinxinkun B, tanshinxinkun C and other 9 ingredients) | 2002 (NMPA, China) | This product is used for acne, tonsillitis, otitis externa, boils, carbuncles, Traumatic infections, burn infections, mastitis, cellulitis, osteomyelitis, etc. |
It has broad-spectrum antibacterial effect, with strong antibacterial activity against Staphylococcus aureus, Mycobacterium tuberculosis, Mycobacterium avium, Mycobacterium acnes, Trichophyton rubrum, Trichophyton rubrum, and Bacillus anthracis |
| Danshen Chuanxiongzin Injection | Injections | Danshen, Chuanxiongzin Hydrochloride | 2004 (NMPA, China) | For occlusive cerebrovascular diseases, such as cerebral blood supply insufficiency, cerebral thrombosis, cerebral embolism, and other ischemic cardiovascular diseases, such as chest tightness, angina pectoris, myocardial infarction, ischemic stroke, thrombo-occlusive vasculitis of coronary heart disease | Anti-platelet aggregation, dilate coronary arteries, reduce blood viscosity, accelerate the flow rate of red blood cells, improve microcirculation, and have anti-myocardial ischemia and myocardial infarction effect |
| Danshen Injection | Injections | Salvia miltiorrhiza | 2002 (NMPA, China) | For coronary heart disease chest tightness, angina pectoris | Invigorate blood circulation, remove blood stasis, dilate the veins and nourish the heart |
| Compound Danshen Tablets | Tablets | Salvia miltiorrhiza, Panax notoginseng, Bingzhi | 2002 (NMPA, China) | Treating chest paralysis caused by Qi stagnation and blood stasis, which is characterized by chest tightness and stabbing pain in the precordial region; coronary angina with the above symptoms | Promoting blood circulation and removing blood stasis, regulating Qi and relieving pain |
| Compound Danshen Drops | Pills | Salvia miltiorrhiza, Panax notoginseng, Bingqi | 1994 (NMPA, China) | Treating chest paralysis caused by Qi stagnation and blood stasis, which is characterized by chest tightness and stabbing pain in the precordial region; coronary angina with the above symptoms | Promoting blood circulation and removing blood stasis, regulating “Qi” and relieving pain |
| Danshen Oral Liquid | Oral solution | Salvia miltiorrhiza | 2005 (NMPA, China) | For chest paralysis, chest tightness and tingling caused by Qi stagnation and blood stasis; angina pectoris in coronary heart disease with the above symptoms | Promote blood circulation, remove blood stasis, dilate the veins and nourish the heart |