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. Author manuscript; available in PMC: 2024 Jan 28.
Published in final edited form as: J Am Chem Soc. 2023 Jun 15;145(25):14019–14030. doi: 10.1021/jacs.3c03887

Figure 1. Semi-synthesis of CoA-αSFL inhibitor.

Figure 1.

(A) Analytical HPLC (gradient: 10-50% B over 30 min) of NCL between CoA-αS1-10 MPAA thioester (5) and αS11-140-C11 (7) to afford the product CoA-αSFL-C11 (8) and desulfurized, purified product CoA-αSFL (9). (B) MALDI-MS of ligation product CoA-αSFL-C11 (8). (C) MALDI-MS of desulfurized final product CoA-αSFL (9).