Table 4.
Fixed-effects logistic regression analysis of stressful life events and risk of relapse
|
Any stressful life events: risk of relapse (unadjusted; n=222) |
Any stressful life events: risk of relapse (with covariates; n=222) |
Number of stressful life events: risk of relapse (unadjusted; n=222) |
Number of stressful life events: risk of relapse (with covariates; n=222) |
||||||
|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | OR (95% CI) | p value | ||
| Any stressful life events before first relapse | |||||||||
| No | .. | .. | 1 (ref) | .. | .. | .. | .. | .. | |
| Yes | 4·33 (2·00–9·37) | 0·0002 | 3·82 (1·82–8·00) | 0·0004 | .. | .. | .. | .. | |
| Number of stressful life events before first relapse | .. | .. | .. | .. | 1·75 (1·25–2·44) | 0·0010 | 1·62 (1·18–2·21) | 0·0028 | |
| Cannabis use | |||||||||
| Former or never | .. | .. | 1 (ref) | .. | .. | .. | 1 (ref) | .. | |
| Intermittent | .. | .. | 1·71 (0·62–4·71) | 0·30 | .. | .. | 1·65 (0·60–4·57) | 0·33 | |
| Continued | .. | .. | 2·35 (1·25–4·39) | 0·0076 | .. | .. | 2·23 (1·19–4·16) | 0·012 | |
| Other drug use | |||||||||
| Non-use | .. | .. | 1 (ref) | .. | .. | .. | 1 (ref) | .. | |
| Experimental | .. | .. | 0·41 (0·11–1·57) | 0·19 | .. | .. | 0·39 (0·10–1·51) | 0·17 | |
| Regular | .. | .. | 1·69 (0·76–3·77) | 0·20 | .. | .. | 1·73 (0·78–3·87) | 0·18 | |
| Medication adherence | |||||||||
| Regular compliance | .. | .. | 1 (ref) | .. | .. | .. | 1 (ref) | .. | |
| Irregular compliance | .. | .. | 1·72 (0·93–3·17) | 0·082 | .. | .. | 1·86 (1·01–3·42) | 0·046 | |
| Poor compliance | .. | .. | 4·11 (1·89–8·94) | 0·0004 | .. | .. | 4·12 (1·89–8·99) | 0·0004 | |
These analyses compare the period when an individual was exposed to stressful life events with the period when the same individual was not exposed to stressful life events. ORs adjusted for covariates take into account time-varying factors: medication adherence, cannabis use pattern, and other drug use. OR=odds ratio.