Table 3.
Association between genetic risk scores and exposures within ALSPAC.
| Outcome | Instrument | F | R2 | N |
|---|---|---|---|---|
| Inflammation | ||||
| Primary analysis | ||||
| Log CRP (mg/l, age 24) | Ligthart et al. (cis) | 26.7 | 1.2 % | 2,222 |
| Han et al. (cis) | 15.8 | 0.7 % | 2,222 | |
| Log IL-6 (pg/ml, age 9) | Ahluwalia et al. (cis) | 87.6 | 2.1 % | 4,184 |
| Rosa et al. (cis) | 76.1 | 1.8 % | 4,184 | |
| GlycA (mmol/l, age 24) | Borges et al. (genome-wide) | 65.7 | 2.7 % | 2,392 |
| Secondary analysis | ||||
| Log CRP (mg/l, age 24) | Ligthart et al. (genome-wide) | 99.9 | 4.3 % | 2,222 |
| Han et al. (genome-wide) | 79.9 | 3.5 % | 2,222 | |
| Log IL-6 (pg/ml, age 9) | Ahluwalia et al. (genome-wide) | 77.3 | 1.8 % | 4,184 |
| Sarwar et al. (cis) | 87.9 | 2.1 % | 4,184 | |
| Swerdlow et al. (cis) | 95.4 | 2.2 % | 4,184 | |
| GlycA (mmol/l, age 24) | Kettunen et al. (genome-wide) | 51.8 | 2.1 % | 2,392 |
| Cognition | ||||
| Working memory (age 24) | Mahedy et al. | 59.7 | 2.3 % | 2,534 |
| Emotion recognition (age 24) | Mahedy et al. | 112.1 | 4.1 % | 2,626 |
| Response inhibition (age 24) | Mahedy et al. | 112.1 | 4.3 % | 2,508 |