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. Author manuscript; available in PMC: 2023 Dec 19.
Published in final edited form as: Cell Rep. 2023 Oct 3;42(10):113188. doi: 10.1016/j.celrep.2023.113188

Figure 5. MC3R regulates downstream MC4R-mediated anorexigenic activity thorough its action in AgRP neurons.

Figure 5.

(A and B) Food intake and percentage change of 24-h body weight in AgRP-Cre and AgRP-specific MC3R KO male mice given saline or setmelanotide injection (2 mg/kg, i.p.) (n = 7–8 mice for each group).

(C and D) Food intake and percentage change of 24-h body weight in AgRP-Cre and AgRP-specific MC3R KO female mice given saline or setmelanotide injection (2 mg/kg, i.p.) (n = 8–9 mice for each group).

Data are plotted as mean, and all error bars represent the SEM. ns, non-significant; *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 in two-way ANOVA with Sidak’s post hoc test.