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XTX101 was activated by human tumor samples in an ex vivo assay. Resected biopsy tumor samples from human patients of listed indications were mechanically disaggregated and cultured in medium for 1–4 days. The supernatant was harvested and incubated with XTX101 for 2–4 days. After incubation, XTX101 was assessed for activation, as determined by CTLA-4 binding ELISA. NSCLC, non-small cell lung cancer; RCC, renal cell carcinoma; TCM, tumor conditioned media.
