Table 1.

Standard Protocol Items: Recommendations for Interventional Trials schedule for enrolment, interventions and assessments

Study period
Time point	Enrolment	Allocation	Post-allocation				Close-out
	The day before surgery	Day of surgery	T1	T2	T3	T4	7 days after surgery
Enrolment:
Eligibility screen	X
Informed consent	X
Allocation		X
Interventions:
Cerebral oximetry guided anaesthetic management
Usual anaesthetic care
Assessments:
Baseline variables	X	X
Haemodynamic parameters			X	X	X	X	X
Follow-up variables							X

T1, before anaesthetic induction; T2, after anaesthetic induction; T3, during surgery; T4, after surgery.