Table 2.
Univariable and multivariable logistic regression models for the original and refined model for early CRP kinetics
| Original model | Refined model | |||||
| Variable | Univariable analysis | Multivariable analysis | Multivariable analysis | |||
| OR (95% CI) | P value | OR (95% CI) | P value | OR (95% CI) | P value | |
| Age (continuously coded) | 1.028 (1.003 to 1.034) | 0.022 | 1.025 (1.006 to 1.045) | 0.011 | 1.023 (1.004 to 1.043) | 0.031 |
| Sex Male Female |
1 (reference) 0.771 (0.528 to 1.126) |
0.178 | ||||
| ECOG ECOG 1 ECOG>1 |
1 (reference) 0.690 (0.395 to 1.204) |
0.191 | ||||
| Charlson Index | 0.995 (0.889 to 1.026) | 0.209 | ||||
| Baseline CRP Low (<median) High (≥median) |
1 (reference) 0.676 (0.465 to 0.983) |
0.040 | 1 (reference) 0.584 (0.386 to 0.886) |
0.011 | 1 (reference) 0.631 (0.401 to 0.993) |
0.046 |
| Cancer type NSCLC Melanoma RCC UC Other |
1 (reference) 1.270 (0.761 to 2.120) 1.078 (0.606 to 1.918) 0.526 (0.233 to 1.188) 0.714 (0.424 to 1.203) |
0.361 0.797 0.122 0.206 |
||||
| Metastatic sites | 0.988 (0.831 to 1.175) | 0.896 | ||||
| Stage at ICI start II+III IV |
1 (reference) 0.284 (0.126 to 0.641) |
0.002 | 1 (reference) 0.319 (0.130 to 1.780) |
0.012 | 1 (reference) 0.294 (0.121 to 0.716) |
0.007 |
| Treatment line 1st line 2nd line or higher |
1 (reference) 0.448 (0.307 to 0.655) |
<0.001 | 1 (reference) 0.500 (0.333 to 0.751) |
0.001 | 1 (reference) 0.496 (0.330 to 0.744) |
0.001 |
| Additional treatments No additional treatment Radiotherapy Chemotherapy Targeted therapy |
1 (reference) 1.413 (0.418 to 4.774) 1.454 (0.795 to 2.658) 2.356 (0.707 to 7.852) |
0.577 0.224 0.163 |
||||
| CRP response CRP non-responder CRP responder CRP flare-responder |
1 (reference) 4.230 (2.714 to 6.593) 3.030 (1.639 to 5.603) |
<0.001
<0.001 |
1 (reference) 4.803 (3.001 to 7.687) 3.026 (1.603 to 5.714) |
<0.001
0.001 |
||
| CRP response CRP non-responder CRP responder CRP flare-responder All-normal CRP |
1 (reference) 4.385 (2.702 to 7.117) 3.310 (1.741 to 6.294) 4.992 (2.592 to 9.614) |
<0.001
<0.001 <0.001 |
1 (reference) 5.024 (3.006 to 8.398) 3.246 (1.672 to 6.301) 3.937 (1.955 to 7.929) |
<0.001
0.001 <0.001 |
||
significant p-values are highlighted in bold
CRP, C reactive protein; ECOG, Eastern Cooperative Oncology Group performance score; ICI, immune checkpoint inhibitor; NSCLC, non-small cell lung cancer; RCC, renal cell carcinoma; UC, urothelial carcinoma.