Table 1.

Information recorded on TIMC-BRAiN case report form

Item	Data recorded
Demographic information
Age	Age at assessment (years)
Sex	Biological sex (male/female/non-binary)
Level of education	Finished formal education (years)
Occupation	Occupation (free text)
Age retired	Age at retirement (years)
Marital status	Non-married/married/divorced/widowed
Driving status	Currently driving/ceased driving/never drove
Medical history
Prior stroke/transient ischaemic attack	Yes/no
Recurrent syncope	Yes/no
Diabetes mellitus5	History of/on diabetes mellitus medication; yes/no
Hypertension	History of/on antihypertensive medication; yes/no
Hypercholesterolaemia	History of/on antilipidaemic medication; yes/no
Ischaemic heart disease	Yes/no
Alcohol excess	Yes/no
Epilepsy	History of/on antiepileptic medication; yes/no
Concussion/prior head injury	Yes/no
History of malignancy	Yes/no
Previous anxiety	History of/on anxiolytic medication; yes/no
Previous depression	History of/on antidepressant medication; yes/no
Hearing impairment	Yes/no
Vision impairment	Yes/no
Smoking status	Yes/no/previous smoker
Family history	Memory difficulties/dementia/Alzheimer’s disease/in a first-degree relative; yes/no
Regular medications	Medications list; coded using anatomical therapeutic classification system
Anosmia	Yes/no
Cognitive symptoms at presentation
Symptom duration	Duration of symptoms (in months)
Episodic memory	Each item recorded as yes/no indicating recent change at time of assessment
Lose track of days Forgetting appointments Misplacing objects Forgetting to pay bills Forgetting how to use appliances Remembering to take medications
Autobiographical memory	Recorded as yes/no indicating recent change at time of assessment
Forgetting past personal events
Language	Each item recorded as yes/no indicating recent change at time of assessment
Word-finding difficulties Shrinkage of vocabulary Comprehending Speech Comprehending written information Ability to engage in conversations
Recognition	Each item recorded as yes/no indicating recent change at time of assessment
Facial recognition Getting lost in familiar areas Changes in using public transport/driving
Informant concerns	Each item recorded as yes/no indicating recent change at time of assessment
Issues with cooking Issues with orientation Issues with driving Issues with medication compliance Recent falls
Cognitive assessment
RBANS	Repeatable Battery for Assessment of Neuropsychological Status Unadjusted (Raw) score and centile score computed (based on age/education) Normalisation using Duff norms
Index I (immediate memory) Index II (visuospatial/constructional) Index III (language) Index IV (attention) Index V (delayed memory) Global score
ACE-III	Addenbrooke’s Cognitive Assessment if unable to complete RBANS Domain and total scores recorded
Attention Memory Fluency Language Visuospatial Overall score
CDR	Clinical Dementia Rating Scale Global score and sum of boxes recorded
Memory Orientation Judgement and problem solving Community affairs Home and hobbies Personal care
FAB	Frontal Assessment Battery Total score recorded
AD8 administered to informant	Ascertain-Dementia 8 Questionnaire (scored from 8)
CBI-R	Cambridge Behavioural Inventory-Revised
Mood and anxiety assessment
HADS-Depression  HADS-Anxiety	Hospital Anxiety and Depression Scales Total Score Recorded Probable Depression/Anxiety (Score >10) Recorded
Further clinical assessment
PSQI	Pittsburgh Sleep Quality Index (0–21)
TUG	Timed-Up-and-Go Test; Time to Complete in seconds recorded
CFS	Clinical Frailty Scale to Assess Frailty
MNA	Mini Nutritional Assessment Score (0–7: malnourished; 8–11: at risk and 12–14: normal)
Neuroimaging
MRI brain	Adjudicated at MDT consensus meeting by a panel of more than two geriatricians/neurologists Fazekas Score 0–3 for white matter disease MTA Score 0–4 Koedam Score for Parietal Atrophy Score 0–3
Fazekas Score MTA Score Koedam Score
CT brain results	CT brain results if performed; free text
FDG-PET results	FDG-PET results if performed; free text
DAT results	DAT scan results if performed; free text
Blood test results
Haematology results	Any abnormalities detected; yes/no; recorded in standard units as per hospital laboratory
Full blood count
Biochemistry and other results	Any abnormalities detected; yes/no; recorded in standard units as per hospital laboratory
Renal profile Liver profile Bone profile Glycated haemoglobin Lipid profile Micronutrients: vitamin B12 and folate Vitamin D
Cerebrospinal fluid results
Diagnostic lumbar puncture results	All recorded as pg/mL using Roche Elecsys electrochemiluminesence assay
Aβ1–42 T-Tau P-Tau
Working (consensus meeting) diagnosis
Working diagnosis at weekly MDT meeting	Free text
Final (biobank) diagnosis
Final diagnosis adjudicated following all investigations	Functional status
	Subjective memory complaints Mild cognitive impairment Dementia
	Aetiological diagnosis
	Alzheimer’s disease (amnestic, behavioural, LPA, CBS and PCA variants) Lewy body disease FTD (bvFTD/nfvPPA/svPPA) FTD overlap syndromes: FTD-ALS/FTD-CBS/FTD-PSP CBS: 4R tauopathy PSP Vascular cognitive impairment/dementia Other diagnosis (free text) Genetic diagnosis (free text)

ACE, Addenbrooke’s Cognitive Assessment; ALS, amyotrophic lateral sclerosis; bvFTD, behavioural variant FTD; CBS, corticobasal syndrome; DAT, dopamine transporter scan; FDG, fluorodeoxyglucose; FTD, frontotemporal dementia; LPA, logopenic variant aphasia; MDT, multidisciplinary team; MTA, medial temporal atrophy; nfvPPA, non-fluent agrammatic PPA; PCA, posterior cortical atrophy; PET, positron emission tomography; PPA, primary progressive aphasia; PSP, progressive supranuclear palsy; 4R Tau, 4 repeat tauopathy; svPPA, semantic variant PPA.