Table 1.
Schedule of assessments
| Screening | Double-blind period | |||
| Screening/ baseline assessment | Randomisation | 1–5 months | 6 months | |
| Study visit (onsite or telehealth) | X | X | ||
| Telephone interview (monthly) | X | |||
| Informed consent | X | |||
| Knee X-ray | X | |||
| Blood test | X | |||
| Medical history/conditions | X | X | ||
| Medication | X | X | ||
| Employment and education | X | |||
| Smoking and alcohol | X | |||
| Questionnaires | ||||
| Knee VAS | X | X | X | |
| WOMAC | X | X | ||
| PainDETECT | X | X | ||
| Hand VAS | X | X | X | |
| Multisite pain | X | X | ||
| AQoL | X | X | ||
| IPAQ | X | X | ||
| Physical examination | ||||
| Height, weight* | X | X | ||
| Compliance and safety (adverse events) | X | X | ||
| Dispense medication | X | |||
*Height and weight will be self-reported if the visit is via telehealth.
AQoL, assessment of quality of life; IPAQ, international physical activity questionnaire; VAS, Visual Analogue Scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.