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. 2023 Dec 14;11(12):e008067. doi: 10.1136/jitc-2023-008067

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Immune evaluations. (A) Peripheral blood mononuclear cells (PBMC) were obtained from all patients and evaluated for PAP-specific T-cell immunity by fluorescent ELISPOT. A positive immune response (red, pink) was defined as a statistically significant response to the PAP peptide pool compared with media alone and that was at least threefold greater than pretreatment and >1:1 00 000 cells. Black/gray=no significant response, Blank=no data. Red/black=assay performed with fresh cells in real time. Pink/gray=assay performed with cryopreserved cells. Shown are responses for IFNγ release (left) or granzyme B release (right). Sera obtained pretreatment and at weeks 4 and 12 of treatment were evaluated for changes in cytokines and chemokines. Shown are the changes from pretreatment of CXCL9 (B) and CXCL10 (C). Statistical comparisons are by paired t-test, and p<0.05 was considered statistically significant.