Table 2.

Adverse events

	Grade 1	Grade 2	Grade 3	Grade 4
Cardiac
Palpitations		1 (5%)
Endocrine
Adrenal insufficiency			1 (5%)
Hyper/hypothyroidism	1 (5%)	4 (21%)
Gastrointestinal
Abdominal pain		1 (5%)
Bloating		1 (5%)
Diarrhea	3 (16%)	1 (5%)
Dry mouth	1 (5%)
Microcolitis	1 (5%)
Pancreatitis		1 (5%)
General/constitutional
Chills	5 (25%)
Fatigue	8 (42%)		1 (5%)
Fever	2 (11%)
Infusion-related reaction		1 (5%)
Injection site reaction	4 (21%)
Non-cardiac chest pain	1 (5%)		1 (5%)
Lab Investigations
Creatinine increased	1 (5%)
Lipase increased			1 (5%)	1 (5%)
Lymphocyte count decreased			1 (5%)
Amylase increased		2 (11%)	1 (5%)
Metabolism and nutrition
Anorexia		2 (11%)
Hypoalbuminemia	1 (5%)
Musculoskeletal
Arthralgia	1 (5%)
Back pain	1 (5%)	2 (11%)
Generalized muscle weakness	1 (5%)
Pain in extremity	1 (5%)
Nervous system
Dysgeusia	1 (5%)
Headache	1 (5%)
Psychiatric
Insomnia		1 (5%)
Renal system
Hematuria	1 (5%)
Respiratory system
Cough	1 (5%)
Dyspnea	1 (5%)
Sore throat	1 (5%)
Skin
Pruritus	2 (11%)
Rash	2 (11%)	2 (11%)
Urticaria	1 (5%)

Shown are all adverse events that were deemed to be at least possibly related to treatment. The numbers represent the number of patients experiencing a particular event at any point during the treatment period, with the highest grade reported for any single individual.