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. 2023 Mar 13;38(5):678–691. doi: 10.1002/jbmr.4795

Table 3.

Genome‐wide significant associations of SNPs in the GALNT3 genomic region (p < 5 × 10−8) in order of significance

Trait Lead SNP MAF p value β 95% CI low 95% CI high Odds ratio
Total body BMD( 32 ) rs7586085 0.41 8.64 × 10−21 −0.0532 −0.064 −0.042
Femoral neck BMD( 26 ) rs10170839 0.42 1.2 × 10−14 −0.0594 −0.074 −0.045
Type 2 diabetes( 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 ) rs11686403 0.41 9.68 × 10−11 −0.022 −0.028 −0.017 0.098
Lumbar spine BMD( 26 ) rs11680288 0.42 3.12 × 10−9 −0.0542 −0.072 −0.037
Phosphate rs777356 0.48 2.73 × 10−5 −0.01019 −0.015 −0.0054
eBMD( 28 ) rs12692777 0.40 7.20 × 10−4 −0.0117 −0.018 −0.005
Forearm BMD( 26 ) rs34100816 0.27 1.78 × 10−3 −0.0527 −0.085 −0.02

Note: Lead SNPs for estimated BMD from heel ultrasound (eBMD), forearm BMD, and phosphate are also shown, although these did not reach genome‐wide significance.

Abbreviations: BMD, bone mineral density; CI, confidence interval; eBMD, bone mineral density estimated from heel ultrasound; LDL, low‐density lipoprotein; MAF, minor allele frequency; SNP, single nucleotide polymorphism; β, beta value.