Fig. 4.

PD-L1 variations in WJ-MSCs to affect therapeutic benefits of for autoimmune hepatitis in mice. A Phenotypes of mouse livers in different groups 24 h after MSCs injections. Mice were intravenously injected with 12 mg/kg ConA, followed by intravenous injection with PBS, WJ-MSCs11 or WJ-MSCs45, respectively. n = 8 in each group. B Quantification of serum ALT and AST levels. n = 8. C Representative H&E staining images of liver histopathology from four different group mice. Scale bar: 100 μm. D Quantification of TUNEL-positive cells in four group mice, wild-type, PBS-, WJ-MSCs11-, and WJ-MSCs45- treatment after ConA injection. Scale bar: 20 μm. E. Quantification of IL-6, IL-1β, IFN-γ, and TNF-α in serum from four different group mice by flow cytometry. n = 6 in each group. t tests were performed. Statistical significance is indicated by ^*P < 0.05, ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001