Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Dec 18;21:362. doi: 10.1186/s12964-023-01394-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

PMC Copyright notice

Fig. 4 — PHPS1 alleviates renal inflammation in db/db mice. A-C WT and db/db mice were adminstrated i.p. with 8 mg/kg/d PHPS1 for 12 weeks, starting at 8 weeks to 20 weeks of age. Injecton of equal volume of vehicle was used as control (Ctrl). Each group included 6 mice. The mRNA level of TNF-α (A), IL-6 (B), and CCL-2 (C) in renal tissue of each group mice was quantified by qRT-PCR analysis. Student’s test, **, p < 0.01; NS, not significant (n = 6). D CCL-2 in kidney tissue isolated from each group was stained by IHC experiment (upper). The immunofluorescent detection of F4/80 (red dots) was used to evaluate renal macrophage infiltration (lower). E The number of F4/80⁺ infiltrated macrophages as shown in (D) was quantified and the percentage of these cells in each group was presented. Student’s test, *, p < 0.05; NS, not significant (n = 6)