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. 2023 Dec 5;14:1287256. doi: 10.3389/fimmu.2023.1287256

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Copyright © 2023 Visser, Nelemans, He, Lourens, Corrales, Huls, Wiersma, Schuringa and Bremer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression pattern, genomic arrangement and transcript variants of the SIRP family. (A) Schematic representation of the protein coding and non-coding transcript variants of the SIRP-ß2 locus. (B) Quantitative RT-qPCR analysis of mRNA expression in T cells and monocytes of SIRP family transcripts. (C) mRNA SIRP-ß2 expression in hierarchical differentiation tree. (D) Colony percentage of BFU-E (Burst Forming Unit E), CFU-GM (Colony-Forming Unit for granulocytes and macrophages) after 14days. 1x10³ CD34+ cells derived from cord blood (CB) plated, transduced with NT, EV and SIRP-ß2. (E) Confocal images of the surface expression of CD11b and SIRP-ß2 on monocytes. (F) Flow cytometry of SIRP-ß2 levels on monocytes (n=11), monocyte-derived macrophages (n=8) and polymorphonuclear neutrophil (PMN) (n=11), including different donors. (G) SIRP-ß2 expression pattern on flow cytometry from 2 different donors.