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. 2023 Dec 19;20:306. doi: 10.1186/s12974-023-02992-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — In vivo genetic silencing of FGF14 mitigates altered plasticity of hippocampal neurons in eCM. A Left: timeline of stereotaxic surgery, P. chabaudi infection, and field recordings. Right: schematic of HFS protocol used in D. B fEPSP slope plotted as a function of stimulation intensity to assess basic synaptic responses in slices from the indicated experimental groups. C Comparison of PPF among the indicated experimental groups. D Comparison of activity-dependent plasticity among the indicated experimental groups. Data are mean ± SEM (n = 9–14 slices/group; slices from N = 4 mice per group). Statistical significance was assessed using a one-way ANOVA with post hoc Tukey’s multiple comparisons test. In (C, right and D, bottom right): ns not significant; ***p < 0.001; ****p < 0.0001