Fig. 3.

Technical and biological sources of variance in noninvasive samples. a Factors contributing to variance in gene expression across tissues as determined by mixed linear modeling. b Principal component analysis using DESeq2 normalized counts and the top 1000 most variable genes. c GEDIT cell type proportion estimates across collections per donor. Only donors with samples passing QC for all collections are displayed here. Niche cell types were collapsed into larger categories (Supp. Fig. 7b), and the top 25% most abundant cell type categories across tissues are shown