Table 2.
Postoperative characteristics of 210 patients with ARDS after cardiac surgery, grouped by CPB time
| Total | Non CPB | Short CPB time | Long CPB time | P value | |
|---|---|---|---|---|---|
| Laboratory data, mean ± SD | |||||
| WBC (109/L) | 14.8 ± 6.3 | 15.1 ± 4.6 | 14.6 ± 7.0 | 14.8 ± 6.8 | 0.931 |
| Hb (g/L) | 87.7 ± 15.4 | 93.7 ± 15.4 | 87.3 ± 15.8a | 83.9 ± 13.8b | 0.001 |
| Sodium (mmol/L) | 143.8 ± 7.2 | 139.4 ± 6.0 | 144.5 ± 16.3 | 146.2 ± 6.9b | 0.004 |
| Potassium (mmol/L) | 4.3 ± 1.0 | 3.9 ± 0.8 | 4.2 ± 1.0 | 4.8 ± 0.9 b,c | < 0.001 |
| BUN (mmol/L) | 32.4 ± 15.2 | 20.7 ± 7.9 | 33.2 ± 15.3a | 40.0 ± 13.9 b,c | < 0.001 |
| Lactate (mmol/L) | 8.8 ± 4.6 | 6.2 ± 4.2 | 9.3 ± 3.8a | 10.1 ± 4.9b | < 0.001 |
| Central venous pressure (cmH2O), mean ± SD | 11.7 ± 3.4 | 10.7 ± 2.4 | 11.9 ± 3.6 | 12.2 ± 3.6 | 0.041 |
| Postoperative LVEF (%), mean ± SD | 51.3 ± 10.6 | 52.3 ± 9.7 | 51.1 ± 10.0 | 50.8 ± 11.7 | 0.697 |
| PaO2/FIO2 ratio | 131.2 ± 49.5 | 147.7 ± 50.3 | 129.6 ± 49.3 | 121.3 ± 49.5b | 0.009 |
| ARDS severity, n (%) | 0.012 | ||||
| Mild | 19 (9.0) | 8 (14.5) | 6 (7.8) | 5 (6.4) | 0.243 |
| Moderate | 126 (60.0) | 38 (69.1) | 45 (58.4) | 43(55.1) | 0.254 |
| Severe | 65 (31.0) | 9 (16.4) | 26 (33.8)a | 30 (38.5)b | 0.020 |
| APACHE II score | 18.9 ± 5.5 | 17.8 ± 5.0 | 18.1 ± 4.9 | 20.4 ± 6.0b,c | 0.009 |
| Tracheotomy, n (%) | 49 (23.3) | 9 (16.4) | 24 (31.2) | 16 (20.5) | 0.106 |
| Duration of invasive ventilation (h) |
173.5± (72.0-301.75) |
181.3± (60–229) |
159± (72–228) |
234± (94–372) b |
0.030 |
| life support treatment, n (%) | |||||
| IABP | 50 (23.8) | 12 (21.8) | 21 (27.3) | 17 (21.8) | 0.669 |
| CRRT | 69 (32.9) | 20 (36.4) | 29 (37.7) | 20 (25.6) | 0.228 |
| ECMO | 40 (19.0) | 8 (14.5) | 13 16.9() | 19 (24.4) | 0.304 |
| Length of stay, median (IQR) | |||||
| ICU LOS | 9.0 (4.0–15.0) | 6.0 (2.0–13.0) | 10.0 (4.5–14.5) | 10.5 (6.0-17.3) b | 0.011 |
| Hospital LOS | 25.0 (16.0-39.3) | 27.0 (21.0–42.0) | 24.0 (17.0–37.0) | 21.5 (14.0–39.0) | 0.096 |
| Mortality, n (%) | |||||
| ICU mortality, n (%) | 44 (21.0) | 3 (5.5) | 15 (19.5) | 26 (33.3) b | < 0.001 |
| Hospital mortality, n (%) | 88 (41.9) | 16 (29.1) | 31 (40.3) | 41 (52.6) b | 0.024 |
Short CPB time = 0 < CPB < 173 min, long CPB time = CPB 173 ≥ minutes
WBC = white blood cell, Hb = hemoglobin, BUN = blood urea nitrogen, IABP = intra-aortic balloon pump, CRRT = continuous renal replacement therapy, ECMO = extracorporeal membrane oxygenation, ICU = intensive care unit