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. 2023 Dec 19;11:203. doi: 10.1186/s40478-023-01684-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — miR-211 expression is downregulated in MB. A Violin plot showing distribution of normalized expression of miR-211 in the 4 molecular subgroups (WNT: 11, SHH: 250, Group 3: 219, Group 4: 326) of MB patients from the MAGIC cohort (n = 806). B Heatmap of differential miRNA expression in six MB cell lines (SHH: DAOY and ONS-76, Group 3: D341 and D425, Group 4: CHLA-01-MED and CHLA-01R-MED). Gene expression data were obtained using human small RNA-seq. Expression values shown are z-scores. C Normalized expression of miR-211 in the MB cell lines from small RNA-seq. D, E Expression of miR-211 in SSH, Group 3, and Group 4 MB cell lines (D) and patient-derived xenograft (PDX) samples E was detected by qRT-PCR. Values indicate fold change relative to normal cerebellum (CB). F Representative images of CISH for miR-211-positive normal cerebellum tissue (left panel). Scatter plot showing miR-211 staining score in normal cerebellum and different MB subgroups (right panel). Magnification × 400. Arrowhead, miR-211-positive cells. Data, mean ± SD. **P < 0.01, ***P < 0.001