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The mechanism of large and hyperreactive platelet production by megakaryocytes in response to radiation injury. IR ionizing radiation, mMK mature megakaryocyte, MOMP mitochondrial outer membrane permeabilization, mtDNA mitochondrial DNA, cGAS cyclic GMP-AMP synthase, STING stimulator of interferon genes, IFN-β interferon-β, STAT1 signal transducer and activator of transcription 1, GBP2 guanylate-binding protein 2
