. 2023 Dec 5;5:1258861. doi: 10.3389/ftox.2023.1258861

TABLE 1.

Species, physiology, and aerosol properties used in each MPPD simulation.

		Physiology				Aerosol properties
Species	Position	Breathing modality	Activity	Tidal Vol. (ml/breath)	Frequency (BPM)	Conc. (mg/m³)	MMAD (µm)	GSD	Density (g/cm³)	Inhalability adjustment (yes/no)
SD rat, asymmetric, 300 g BW	Upright	Nose only	Resting	2.12614 (scaled by BW)	166	5212 ^a	2.74 ^a	2.8 ^a	1.0	Yes
SD rat, asymmetric, 300 g BW	Upright	Nose only	Resting	2.12614 (scaled by BW)	166	2000 ^b	2.01	3.0	1.0	Yes
SD rat, asymmetric, 300 g BW	Upright	Nose only	Resting	2.12614 (scaled by BW)	166	1084 ^a	2.01 ^a	3.0 ^a	1.0	Yes
Human, Yeh and Schum, symmetric	Upright	Nasal	Resting	625 (default)	12 (default)	5212	2.74	2.8	1.0	No
Human, Yeh and Schum, symmetric	Upright	Oral	Resting	625 (default)	12 (default)	5212	2.74	2.8	1.0	No

^{^a}

Exposure conditions from Wittmer et al. (2021).

^{^b}

OECD, recommended alternate limit test exposure concentration (OECD, 2009).