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Comparison of brexanolone and zuranolone with placebo groups, respectively.
| Brexanolone (104) | Brexanolone (104) | Brexanolone: placebo group (104) | Zuranolone (2) | Zuranolone: placebo group (2) | |
|---|---|---|---|---|---|
| Mean change from baseline in HAMD-17 score | –19.5 (SE = 1,2) after 60 h | –17.7 (SE = 1,2) after 60 h | –14.0 (SE = 1,1) after 60 h | –17.8 on day 3 | –13.6 on day 3 |
| Dose and population | 60 μg/kg/h in 60 h IV n = 43 |
90 μg/kg/h in 60 h IV n = 41 |
n = 46 | 30 mg/d IP in 14 days n = 77 |
n = 76 |
