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. 2023 Dec 5;14:1320414. doi: 10.3389/fimmu.2023.1320414

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Copyright © 2023 Bai, Li, He, Hong, Yan, Zhao, Lin, Tacke, Engelmann and Hu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Single-cell atlas of healthy, HBV-infected, HBV-cirrhotic, and HBV-HCC livers. (A) Workflow of isolation, sorting, and sc-RNASeq of CD45+ leukocytes from healthy liver to HBV infection, HBV cirrhosis, and HBV HCC using flow cytometry and 10× Genomics platform. (B) Clustering analysis of all the CD45+ leukocytes. (C) The expression of CD4, CD8A, CD8B, CD14, CD19, FCGR3A (CD16), and KLRF1 in UMAP plot. (D) The two most significant marker genes in each cluster displayed in the dot plot. (E) The proportion of T cells, NK cells, myeloid cells, and B cells from healthy liver to HBV infection, HBV cirrhosis, and HBV HCC. (F) Pie chart of the average proportion of T cells, NK cells, myeloid cells, and B cells from healthy liver to HBV infection, HBV cirrhosis, and HBV HCC.