Table 2.
Hemodynamic Measurements
| Entire cohort (N = 70) [mean ± SD] | No early RHF (N = 43) [mean ± SD] | Early RHF (N=27) [mean ± SD] | p-value | |
|---|---|---|---|---|
|
| ||||
| Baseline hemodynamics | ||||
| MAP (mmHg) | 83 ± 9 | 82 ± 9 | 85 ± 8 | 0.185 |
| PAPM (mmHg) | 41 ± 7 | 40 ± 7 | 43 ± 7 | 0.044 |
| CI (L/min/m2) | 1.65 ± 0.36 | 1.66 ± 0.36 | 1.62 ± 0.36 | 0.669 |
| RAP (mmHg) | 11 ± 5 | 10 ± 4 | 12 ± 6 | 0.134 |
| PAWP (mmHg) | 25 ± 5 | 24 ± 5 | 25 ± 6 | 0.305 |
| RAP:PAWP | 0.45 ± 0.19 | 0.43 ± 0.18 | 0.49 ± 0.21 | 0.223 |
| PVR (Wood units) | 5.2 ± 2.2 | 4.9 ± 2.1 | 5.6 ± 2.3 | 0.248 |
| SVI (mL/m2) | 19 ± 6 | 21 ± 6 | 17 ± 5 | 0.01 |
| Pulmonary Ea (mmHg/mL) | 1.72 ± 0.64 | 1.58 ± 0.56 | 1.94 ± 0.70 | 0.021 |
| Pca (mL/mmHg) | 1.34 ± 0.68 | 1.40 ± 0.78 | 1.24 ± 0.50 | 0.342 |
| PAPi(mmHg) | 3.9 ± 3.0 | 4.3 ± 3.5 | 3.2 ± 1.9 | 0.155 |
| SVR (dynes/sec/cm−5) | 1807 ± 477 | 1796 ± 458 | 1824 ± 514 | 0.82 |
| HR (bpm) | 89 ± 20 | 83 ± 17 | 99 ± 22 | 0.001 |
| Delta: Peak - Baseline | ||||
| MAP (mmHg) | −14 ± 8 | −14 ± 9 | −14 ± 8 | 0.754 |
| PAPM (mmHg) | −11 ± 7 | −11 ± 7 | −12 ± 8 | 0.472 |
| CI (L/min/m2) | 0.58 ± 0.50 | 0.73 ± 0.52 | 0.35 ± 0.37 | 0.001 |
| PAWP (mmHg) | −7 ± 6 | −8 ± 5 | −7 ± 7 | 0.655 |
| PVR (Wood units) | −2.0 ± 2.1 | −2.1 ± 2.0 | −1.8 ± 2.3 | 0.662 |
| SVI (mL/m2) | 7.5 ± 7.2 | 9.2 ± 7.5 | 4.7 ± 6.0 | 0.011 |
| Pulmonary Ea (mmHg/mL) | −0.76 ± 0.48 | −0.75 ± 0.41 | −0.76 ± 0.59 | 0.98 |
| HR (bpm) | −2 ± 10 | −1 ± 7 | −3 ± 13 | 0.51 |
| Peak Vasodilator Hemodynamics | ||||
| Nitroprusside dose (mcg/kg/min) | 1.7 ± 1.6 | 1.8 ± 1.9 | 1.7 ± 1.2 | 0.816 |
| MAP (mmHg) | 69 ± 9 | 67 ± 10 | 71 ± 8 | 0.121 |
| PAPM (mmHg) | 30 ± 7 | 29 ± 6 | 31 ± 7 | 0.179 |
| CI (L/min/m2) | 2.23 ± 0.57 | 2.39 ± 0.62 | 1.97 ± 0.36 | 0.001 |
| PAWP (mmHg) | 17 ± 6 | 16 ± 6 | 18 ± 7 | 0.243 |
| PVR (Wood units) | 3.1 ± 1.4 | 2.9 ± 1.3 | 3.4 ± 1.6 | 0.152 |
| SVI (mL/m2) | 27 ± 9 | 30 ± 9 | 22 ± 7 | <0.001 |
| Pulmonary Ea (mmHg/mL) | 0.97 ± 0.44 | 0.83 ± 0.31 | 1.19 ± 0.52 | 0.002 |
| HR (bpm) | 88 ± 20 | 82 ± 17 | 96 ±22 | 0.004 |
Abbreviations: CI, cardiac index; Ea, effective arterial elastance; HR, heart rate; MAP, mean arterial pressure; PAPi, pulmonary arterial pulsitility index; PAPM, mean pulmonary arterial pressure; PAWP, pulmonary arterial wedge pressure; Pca, pulmonary arterial compliance; PVR, pulmonary vascular resistance; RAP, right atrial pressure; SD, standard deviation; SVI, stroke volume index; SVR, systemic vascular resistance.
Values are presented as mean ± standard deviation unless otherwise indicated.