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. 2023 Dec 7;5(6):fcad344. doi: 10.1093/braincomms/fcad344

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Adult wild-type mice treated with Htt-KamiCas9 are not statistically different from their controls in behavioural analyses. (A) Diagram depicting the experimental setting for the inactivation of Htt in wild-type mice (FVB strain) and the behavioural, neuropathological, biochemical and molecular analyses performed (n = 17 mice/group; created with Biorender.com). (B) Coat hanger test; (C) grip strength; (D) balance beam walking performed on square beams (sq) and round beams (rd) of various widths; (E) Open-field locomotion; (F) accelerating rotarod (G) or rotarod performance; (H) gait analysis (frontlimb (Fr) and hindlimb (Hi)) and (I) anxiety-related variables measured in open-field conditions at nine months of age. Statistics: unpaired t-tests, after verification of the assumptions of equal variance and normal distribution of the data. For datasets violating parametric assumptions (e.g. coat hanger data), group comparisons were performed with the Mann–Whitney U-test.