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. 2023 Dec 7;5(6):fcad344. doi: 10.1093/braincomms/fcad344

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© The Author(s) 2023. Published by Oxford University Press on behalf of the Guarantors of Brain.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Single-nuclei RNA-seq. (A) Uniform manifold approximation and projection (UMAP) of 108 550 cells by identified cell type, from Malaiya and coworkers (n = 4 animals/group). D1 dopamine receptor (Drd1) or D2 dopamine receptor (Drd2) spiny projections neurons (SPN), somatostatin (SST), parvalbumin (Pvalb), and choline acetyltransferase (Chat) and interneurons (IN) were identified. (B) Augur analysis. The area under the receiver operating characteristics curve (AUC) is only slightly larger than that expected by chance (0.5) for all cell types, indicating an absence of major differences between the control and HTT KO for any cell type. (C) Chromosomal localization of long non-coding RNAs (lncRNAs) differentially expressed in SPNs. (D) Distribution of repeats and transposable elements in lncRNAs differentially expressed (DE) in SPNs relative to total genome lncRNAs.