Table 1.

Relevant miRNAs and targets previously identified in the literature and associated with IBS pathophysiology in clinical and animal studies.

	mRNA		miRNA
Group	Up	Down	Up	Down	Biological role
Cluster 1		Srf		miR-143-3p	GI motility26
		Slc6a4 (Sert)		miR-200a-3p	Visceral hyperalgesia27
		Aqp3	miR-29a-3p		Intestinal permeability28
		Pten		miR-21-5p	Intestinal barrier function29
		Cdh1		miR-219a-5p	Intestinal barrier function and visceral nociception30
		Cacna1c	miR-342-3p		Colonic motility, pain signaling, and smooth muscle function31
				miR-338-3p	Intestinal permeability and visceral nociception30
	Aqp8		miR-29a-3p		Intestinal permeability28
		Ocln	miR-122-5p		Intestinal barrier function32
		Myocd			Regulation of GI smooth muscle cell phenotype26
		Tjp1 (ZO-1)	miR-29a-3p	miR-219a-5p	Intestinal barrier function30,33
	Pkib				Visceral sensitivity34
	Prdx1				LPS-induced inflammatory damage35
				miR-106b-5p	Mapk signaling pathway36
				miR-148a-3p	IBS-D symptoms37
				miR-190a-5p	IBS-D symptoms37
				miR-194-5p	IBS-D symptoms37