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. 2023 Nov 27;15(2):2282789. doi: 10.1080/19490976.2023.2282789

Figure 2.

Figure 2.

Cldn3KO mice are susceptible to colitis.

Cldn3KO mice and WT littermates were subjected to murine models of colitis to evaluate the role of colonic CLDN3 in IBD. (a) % change in body weight of Cldn3KO mice during acute DSS colitis; (b and c) Colon length and colon thickness in Cldn3KO mice versus WT littermates upon acute DSS treatment; (d) Disease activity index; (e and f) Representative H&E images and injury score in Cldn3KO mice subjected to acute DSS colitis; (g and h) Colon length and colon thickness in Cldn3KO mice subjected to chronic DSS colitis; (i and j) Representative H& E images and injury score in Cldn3KO (vs WT) mice subjected to chronic DSS colitis; (k) % change in body weight of Cldn3KO mice subjected to C. rodentium colitis; (l) Colon thickness in Cldn3KO mice versus WT littermates, and (m and n) Representative H&E images and collective injury score in Cldn3KO mice compared to WT littermates. *P < .05, **P < .01, and ***P < .001. Scale bar = 50 μm.