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. 2023 Dec 7;15(2):2290318. doi: 10.1080/19490976.2023.2290318

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© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 6. — Plasma metabolomics associated with serum ferritin, executive function, and semantic memory in the entire cohort. Boxplots of the normalized variable importance measure (VIM) (a and c) and SHAP summary plots (b and d), for the metabolites associated with the SF levels measured by HPCL-ESI-MS/MS in positive (a) and negative (c) models. (e and f) Heatmap displaying the Spearman correlation (adjusted by age, sex, body mass index, and education years) between PVF, SVF, and TDS and the plasma metabolomics in positive mode (e) and negative mode (f). Significant associations are shown with a cross: **** <0.001, ***<0.01, **<0.05, *<0.1.