Table 2.

Significant MR results of causal association between gut microbes and frailty.

Exposure	Method	N.snp	beta	95%CI	p
Clostridium innocuum	Inverse variance weighted	9	0.023	(0.001,0.044)	0.036
Clostridium innocuum	RAPS	9	0.024	(0.001,0.046)	0.043
Eubacterium coprostanoligenes	Weighted median	13	0.068	(0.020,0.116)	0.006
Eubacterium coprostanoligenes	Inverse variance weighted	13	0.054	(0.019,0.090)	0.003
Eubacterium coprostanoligenes	RAPS	13	0.055	(0.016,0.094)	0.005
Eubacterium ruminantium	Inverse variance weighted	18	−0.027	(−0.051,-0.003)	0.028
Eubacterium ruminantium	RAPS	18	−0.029	(−0.050,-0.008)	0.007
Akkermansia	Inverse variance weighted	10	−0.042	(−0.074,-0.011)	0.009
Akkermansia	RAPS	10	−0.044	(−0.078,-0.010)	0.011
Bifidobacterium	Inverse variance weighted	11	0.044	(0.010,0.079)	0.012
Bifidobacterium	RAPS	11	0.045	(0.009,0.082)	0.015
Butyrivibrio	Inverse variance weighted	13	−0.019	(−0.035,-0.003)	0.020
Butyrivibrio	RAPS	13	−0.020	(−0.037,-0.003)	0.021
Catenibacterium	Inverse variance weighted	4	−0.031	(−0.058,-0.003)	0.030
Catenibacterium	RAPS	4	−0.031	(−0.061,-0.001)	0.046
Christensenellaceae R-7 group	Inverse variance weighted	7	−0.059	(−0.107,-0.011)	0.017
Christensenellaceae R-7 group	RAPS	7	−0.061	(−0.113,-0.008)	0.023
Defluviitaleaceae UCG-011	Weighted median	8	−0.042	(−0.082,-0.002)	0.039
Defluviitaleaceae UCG-011	Inverse variance weighted	8	−0.034	(−0.063,-0.005)	0.024
Defluviitaleaceae UCG-011	RAPS	8	−0.035	(−0.067,-0.004)	0.027
Howardella	Weighted median	9	0.027	(0.001,0.053)	0.047
Howardella	Inverse variance weighted	9	0.024	(0.004,0.045)	0.019
Howardella	RAPS	9	0.025	(0.003,0.046)	0.028
Ruminococcus 1	Weighted median	9	0.069	(0.016,0.122)	0.011
Ruminococcus 1	Inverse variance weighted	9	0.054	(0.013,0.096)	0.010
Ruminococcus 1	RAPS	9	0.057	(0.016,0.098)	0.007
Allisonella	Inverse variance weighted	8	0.032	(0.007,0.057)	0.012
Allisonella	RAPS	8	0.034	(0.013,0.055)	0.001