Table 1.
Studies investigating associations between the gut microbiome and age.
| Country | N | Age | Method of gut microbiome evaluation | Gut microbes associated with increased age | References |
|---|---|---|---|---|---|
| Italy | 69 | 22–109 years | 16S (V3–V4) |
Coprococcus, Roseburia, Faecalibacterium ↓ Oscillospira, Odoribacter, Butyricimonas, Eggerthella, Akkermansia, Anaerotruncus, Synergistaceae, Bilophila, Christensenellaceae ↑ |
Biagi, 201615 |
| China | 168 | 24–83 years 90–102 years |
16S (V4–V5) | Clostridium cluster XIVa, Ruminococcaceae, Akkermansia, Christensenellaceae ↑ | Kong, 201616 |
| South Korea | 890 | 20–90 years | 16S (V3–V4) |
Bacteroides, Oscillospira, Dorea, Blautia, Coprococcus ↓ Streptococcus, Veillonella, Haemophilus, Klebsiella, Prevotella ↑ |
Lim, 202117 |
| Japan | 1596 | 20–83 years | 16S (V3–V4) |
Blautia, Parabacteroides ↓ Roseburia ↑ |
Park, 202118 |
| China | 614 | 19–49 years 50–87 years |
Shotgun |
Alistipes putredinis, Barnesiella intestinihominis, Megamonas funiformis, Parabacteroides merdae, Subdoligranulum unclassified ↓ Bacteroides (B. cellulosilyticus, B. fragilis, B. intestinalis, B. ovatus, Bacteroides sp 4 3 47FAA, B. thetaiotaomicron), Bifidobacterium (B. longum, B. pseudocatenulatum), Clostridium bolteae, Escherichia (E. coli, Escherichia unclassified), Parabacteroides (P. distasonis, Parabacteroides unclassified), Ruminococcus gnavus, Klebsiella pneumoniae, Dialister invisus, Veillonella unclassified, Mitsuokella multacidawere, Coprococcus eutactus ↑ |
Yan, 202219 |
| China Netherlands Israel |
4346 (China: 2,338 Netherlands: 1,133 Israel: 875) |
18–81 years (China: 26–76 years Netherlands: 18–81 years Israel: 18–70 years) |
Shotgun | Common features in three cohorts Bifidobacterium bifidum, Bifidobacterium breve ↓ Campylobacter concisus, Citrobacter koseri, Klebsiella pneumoniae/Klebsiella variicola group, Klebsiella oxytoca, Klebsiella pneumoniae, Veillonella atypica, Streptococcus gordonii, Lactobacillus salivarius, Pseudoflavonifractor capillosus, Clostridium saccharolyticum, Coprococcus catus, Ruminococcus lactaris, Klebsiella variicola/pneumoniae, Butyrivibrio crossotus ↑ |
Zhang, 202120 |