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. 2023 Sep 7;119(16):2623–2637. doi: 10.1093/cvr/cvad143

Figure 6.

Figure 6

Prolonged (7-day) TP-induced remodelling of cellular electrophysiology in atrial engineered human myocardium (aEHM) and atrial induced pluripotent stem cell-derived cardiomyocytes (iPSC-aCM). (A), Representative action potentials (AP) elicited at 1 Hz in aEHM after 7 days of optical pacing at 1 Hz (left) or 3 Hz (right). (B), AP duration at 20, 50, and 90% repolarization (APD20, APD50 and APD90, left), resting membrane potential (RMP, middle left), upstroke velocity (dV/dtmax, middle right), AP amplitude (APA, right; 1 Hz: n = 45/8, 3 Hz: n = 23/9). (C) Representative voltage-clamp recordings of basal inward-rectifier K+ current (IK1) current in iPSC-aCM after 7 day of optical pacing at 1 Hz (left) or 3 Hz (right). (D) Peak IK1 measured at −100 mV (1 Hz: n = 49/1, 3 Hz: n = 64/1). Data are mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. 1 Hz using paired Student’s t-test. n/N = number of iPSC-CM/differentiation or number of recordings/EHM.