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. 2023 Nov 22;26(12):108504. doi: 10.1016/j.isci.2023.108504

Figure 1.

Figure 1

Oral administration of antigen prior to vaccination with alum suppresses Type 2 immune responses

Analysis of endpoint (Day 28) of mice gavaged with PBS (black) or OVA (red) prior to immunization with alum.

(A) Experimental timeline (B) OVA-IgG1 titers and secreted IL-4 upon OVA-re-stimulation of splenocytes after 72 h.

(C) OVA-IgG1 from an individual experiment over time, representative of 3 independent trials.

(D) OVA-IgG2c titers and secreted IFNγ upon OVA-re-stimulation of splenocytes after 72 h.

(E) Ratio of IgG1:IgG2c titers for individual mice. Each data point represents an individual mouse.

Data are pooled from 3 independent experiments and represented as mean ± SD. Unpaired t tests were used for statistical analysis. ∗∗p < 0.01, ∗∗∗∗p < 0.0001.