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. 2023 Nov 22;26(12):108504. doi: 10.1016/j.isci.2023.108504

Figure 3.

Figure 3

Tolerance remains intact in mice lacking RORγt expression in Tregs upon immunization with alum

Analysis of endpoint (Day 28) of mice gavaged with PBS (black) or OVA (red) from control mice (closed symbols) or cKO mice (open symbols).

(A) Experimental timeline.

(B) OVA-IgG1 titers and secreted IL-4 upon OVA-re-stimulation of splenocytes after 72 h.

(C) OVA-IgG2c titers and secreted IFNγ upon OVA-re-stimulation of splenocytes after 72 h.

Data are pooled from 3-4 independent experiments and represented as mean ± SD. Unpaired t tests were used for statistical analysis. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.