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. 2023 Nov 22;26(12):108504. doi: 10.1016/j.isci.2023.108504

Figure 6.

Figure 6

Tolerance maintained in mice lacking RORγt expression in Tregs with Lit4Q adjuvanted immunization

Experimental timeline from Figure 4A was used with Lit4Q as adjuvant in immunization. Control mice (closed symbols) or cKO mice (open symbols) were gavaged with PBS (black) or OVA (red) prior to immunization.

(A) OVA-IgG1 titers and secreted IL-4 upon OVA-re-stimulation of splenocytes after 72 h.

(B) OVA-IgG2c titers and secreted IFNγ upon OVA-re-stimulation of splenocytes after 72 h.

Data are pooled from 2 independent experiments and represented as mean ± SD. Unpaired t tests were used for statistical analysis. ∗∗p < 0.01, ∗∗∗p < 0.001.