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. 2023 Dec 8;5(12):2148–2168. doi: 10.1038/s42255-023-00936-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a. Colon adenocarcinoma (COAD) TCGA dataset: TOP; Prognostic value for overall survival of SLC6A14 transcript levels comparing samples with 25% lowest (SLC6A14^LOW) (n = 57) and 25% highest (SLC6A14^HIGH) (n = 80) expression (left), of SLC12A4 comparing samples with 20% lowest (SLC12A4^LOW) (n = 58) and 20% highest (SLC12A4^HIGH) (n = 58) expression (middle) and of SLC25A15 comparing samples with 20% lowest (SLC25A15^LOW) (n = 58) and 20% highest (SLC25A15^HIGH) (n = 58) expression (right). Bottom; Prognostic value for overall survival of SLC12A4 transcript levels in SLC6A14^HIGH COAD patients with 20% lowest (SLC6A14^HIGH;SLC12A4^LOW) (n = 15) and 20% highest (SLC6A14^HIGH;SLC12A4^HIGH) (n = 15) expression (left) and of SLC25A15 in SLC6A14^HIGH COAD patients with 20% lowest (SLC6A14^HIGH;SLC25A15^LOW) (n = 15) and 20% highest (SLC6A14^HIGH;SLC25A15^HIGH) (n = 15) expression (right). b. Breast invasive carcinoma (BRCA) TCGA dataset: TOP; Prognostic value for overall survival of SLC6A14 transcript levels comparing samples with 25% lowest (SLC6A14^LOW) (n = 277) and 25% highest (SLC6A14^HIGH) (n = 273) expression (left), of SLC12A4 comparing samples with 15% lowest (SLC12A4^LOW) (n = 164) and 15% highest (SLC12A4^HIGH) (n = 164) expression (middle) and of SLC25A15 comparing samples with 25% lowest (SLC25A15^LOW) (n = 276) and 25% highest (SLC25A15^HIGH) (n = 273) expression (right). Bottom; Prognostic value for overall survival of SLC12A4 transcript levels in SLC6A14^HIGH BRCA patients with 10% lowest (SLC6A14^HIGH;SLC12A4^LOW) (n = 28) and 10% highest (SLC6A14^HIGH;SLC12A4^HIGH) (n = 30) expression (left) and of SLC25A15 in SLC6A14^HIGH BRCA patients with 25% lowest (SLC6A14^HIGH;SLC25A15^LOW) (n = 70) and 25% highest (SLC6A14^HIGH;SLC25A15^HIGH) (n = 69) expression (right). c. Pancreatic adenocarcinoma (PAAD) TCGA dataset: TOP; Prognostic value for overall survival of SLC6A14 transcript levels comparing samples with 25% lowest (SLC6A14^LOW) (n = 45) and 25% highest (SLC6A14^HIGH) (n = 45) expression (left), of SLC12A4 comparing samples with 20% lowest (SLC12A4^LOW) (n = 36) and 20% highest (SLC12A4^HIGH) (n = 36) expression (middle) and of SLC25A15 comparing samples with 20% lowest (SLC25A15^LOW) (n = 37) and 20% highest (SLC25A15^HIGH) (n = 40) expression (right). In a-c: Box and whiskers plots are log2 (TPM + 0.001) with boxes representing median and 25^th and 75^th percentiles and whiskers extending from the smallest to the highest value of the data with individual dots showing each point of the dataset. Kaplan–Meier curves were statistically compared using log-rank (Mantel⁻Cox) test.