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. 2023 Dec 18;13:22598. doi: 10.1038/s41598-023-48798-8

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of LAMA3 knockdown on CCA cell proliferation, cell death and cell cycle progression. (a) Efficiency of siLAMA3 on the reduction of LAMA3A expression in CCA compared with those of siNeg treatment at 48 h-post transfection. (b) Cell proliferation of CCA cell transfected with siLAMA3 determining at 72 h-post transfection using MTS assay. (c) Representative flow cytometry scatter plots and quantification for the percentage of apoptosis. (d) Representative area histograms and quantified bar graph for the distribution of cell cycle phases. Data present as mean ± SEM of siLAMA3 relative to siNeg from three independent experiments. Graphs were created using Graphpad Prism. Scatter plots and area histograms of flow cytometry were generated from The BD Accuri™ C6 Plus Flow Cytometer. *P < 0.05, **P < 0.01, ***P < 0.001.