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. 2023 Dec 6;16:1280546. doi: 10.3389/fnmol.2023.1280546

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Copyright © 2023 Gkekas, Vagiona, Pechlivanis, Kastrinaki, Pliatsika, Iben, Xanthopoulos, Psomopoulos, Andrade-Navarro and Petrakis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulated protein pathways due to the sequestration of RNA transcripts in polyQ IIBs. (A) SCA1 PIN illustrating the interactions of proteins corresponding to the RNA transcripts bound on polyQ IIBs (40 genes, adj. p-value < 0.05). Network proteins agglomerated into eight clusters; each were assigned a numeric identifier (1–8). KEGG pathway enrichment analysis indicates the overrepresented function of each cluster. The figure also shows the number of proteins associated with each KEGG term per total proteins of the cluster. (B) Comparative analysis of cytoplasmic/total mRNA ratio for enriched RNA transcripts in (D5) versus (D0) Tet-On YFP-ATXN1(Q82) SH-SY5Y cells (**p-value < 0.01, ***p-value < 0.001).