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. 2023 Dec 19;13:22634. doi: 10.1038/s41598-023-49441-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Total FoxP3⁺ TILs and CD68⁺ TAMs expression in CC patients. Representative IHC images of low and high FoxP3⁺ TILs (a) and CD68⁺ TAMs (d) are indicated by arrows. Scale bar = 50 μm. Morphometric analysis did not show differences in total FoxP3⁺ TILs quantification between the groups (b, NR, n = 32 and R, n = 36) and (c, NR low, n = 16; NR high, n = 16; R low, n = 19 and R high, n = 17). (e) No difference was observed in the number of total CD68⁺ TAMs between the groups (NR, n = 30 and R, n = 34) and (f, NR low, n = 15; NR high, n = 15; R low, n = 19 and R high, n = 15), considering p ≤ 0.05. The p values were calculated using the Mann–Whitney test. The graphs show the median and standard error. CC, cervical cancer; NR, non-responder (Red) patients; R, responder (Blue) patients.