Table 1.
Mediator | Longevity | Total effect β (95% CI) | Direct effect A β (95% CI) | Direct effect B β (95% CI) | Mediation effect β (95% CI) | P value | Mediated proportion (%) |
---|---|---|---|---|---|---|---|
DBP | 90th | −0.57 (−2.12 to 0.97) | −2.65 (−3.97 to -1.32) | -0.068 (−0.082 to −0.054) | 0.18 (0.083 to 0.28) | 0.00029 | 31.48 (14.44 to 48.51) |
DBP | 99th | −1.13 (−3.55 to 1.28) | −2.65 (−3.97 to −1.32) | −0.077 (−0.099 to −0.056) | 0.21 (0.088 to 0.32) | 0.00060 | 28.42 (7.76 to 18.09) |
Hypertension | 90th | −0.57 (−2.12 to 0.97) | 0.081 (0.016 to 0.15) | −5.01 (−6.09 to −3.92) | −0.41(−0.74 to −0.070) | 0.018 | 70.86 (12.23 to 100) |
Hypertension | 99th | −1.13 (−3.55 to 1.28) | 0.081 (0.016 to 0.15) | −5.70 (−7.52 to −3.87) | −0.46 (−0.86 to −0.065) | 0.023 | 40.86 (5.70 to 76.02) |
Hypercholesterolaemia | 90th | −0.57 (−2.12 to 0.97) | 0.072 (0.0070 to 0.14) | −9.61 (−12.95 to −6.27) | −0.69 (−1.36 to −0.023) | 0.043 | 100 (3.92 to 100) |
Hypercholesterolaemia | 99th | −1.13 (−3.55 to 1.28) | 0.072 (0.0070 to 0.14) | −13.13 (−18.87 to −7.38) | −0.94 (−1.89 to 0.0029) | 0.051 | 83.18 (0 to 100) |
Angina pectoris | 90th | −0.57 (−2.12 to 0.97) | 0.045 (0.011 to 0.078) | −0.36 (−0.50 to −0.21) | −0.014 (−0.026 to −0.0022) | 0.020 | 2.45 (0. 39 to 4.50) |
Angina pectoris | 99th | −1.13 (−3.55 to 1.28) | 0.045 (0.011 to 0.078) | −0.39 (−0.58 to −0.20) | −0.017 (−0.033 to −0.0020) | 0.026 | 1.53 (0. 18 to 2.88) |
Hypothyroidism | 90th | −0.57 (−2.12 to 0.97) | 0.092 (0.060 to 0.13) | −3.69 (−7.27 to −0.11) | −0.34 (−0.69 to 0.011) | 0.058 | 59.37 (0 to 100) |
Hypothyroidism | 99th | −1.13 (−3.55 to 1.28) | 0.092 (0.060 to 0.13) | −1.48 (−7.23 to 4.27) | −0.14 (−0.67 to 0.40) | 0.62 | 12.05 (0 to 59.16) |
AD | 90th | −0.57 (−2.12 to 0.97) | 0.48 (0.014 to 0.96) | −0.29 (−0.36 to −0.22) | −0.14 (−0.28 to −0.00016) | 0.05 | 24.65 (0 to 49.27) |
AD | 99th | −1.13 (−3.55 to 1.28) | 0.48 (0.014 to 0.96) | −0.39 (−0.50 to −0.28) | −0.19 (−0.38 to 0.0026) | 0.053 | 16.61 (0 to 33.46) |