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. 2023 Dec 19;9(1):29. doi: 10.1038/s41514-023-00126-0

Table 1.

The mediation effect of PM2.5 concentration on longevity via potential mediators.

Mediator Longevity Total effect β (95% CI) Direct effect A β (95% CI) Direct effect B β (95% CI) Mediation effect β (95% CI) P value Mediated proportion (%)
DBP 90th −0.57 (−2.12 to 0.97) −2.65 (−3.97 to -1.32) -0.068 (−0.082 to −0.054) 0.18 (0.083 to 0.28) 0.00029 31.48 (14.44 to 48.51)
DBP 99th −1.13 (−3.55 to 1.28) −2.65 (−3.97 to −1.32) −0.077 (−0.099 to −0.056) 0.21 (0.088 to 0.32) 0.00060 28.42 (7.76 to 18.09)
Hypertension 90th −0.57 (−2.12 to 0.97) 0.081 (0.016 to 0.15) −5.01 (−6.09 to −3.92) −0.41(−0.74 to −0.070) 0.018 70.86 (12.23 to 100)
Hypertension 99th −1.13 (−3.55 to 1.28) 0.081 (0.016 to 0.15) −5.70 (−7.52 to −3.87) −0.46 (−0.86 to −0.065) 0.023 40.86 (5.70 to 76.02)
Hypercholesterolaemia 90th −0.57 (−2.12 to 0.97) 0.072 (0.0070 to 0.14) −9.61 (−12.95 to −6.27) −0.69 (−1.36 to −0.023) 0.043 100 (3.92 to 100)
Hypercholesterolaemia 99th −1.13 (−3.55 to 1.28) 0.072 (0.0070 to 0.14) −13.13 (−18.87 to −7.38) −0.94 (−1.89 to 0.0029) 0.051 83.18 (0 to 100)
Angina pectoris 90th −0.57 (−2.12 to 0.97) 0.045 (0.011 to 0.078) −0.36 (−0.50 to −0.21) −0.014 (−0.026 to −0.0022) 0.020 2.45 (0. 39 to 4.50)
Angina pectoris 99th −1.13 (−3.55 to 1.28) 0.045 (0.011 to 0.078) −0.39 (−0.58 to −0.20) −0.017 (−0.033 to −0.0020) 0.026 1.53 (0. 18 to 2.88)
Hypothyroidism 90th −0.57 (−2.12 to 0.97) 0.092 (0.060 to 0.13) −3.69 (−7.27 to −0.11) −0.34 (−0.69 to 0.011) 0.058 59.37 (0 to 100)
Hypothyroidism 99th −1.13 (−3.55 to 1.28) 0.092 (0.060 to 0.13) −1.48 (−7.23 to 4.27) −0.14 (−0.67 to 0.40) 0.62 12.05 (0 to 59.16)
AD 90th −0.57 (−2.12 to 0.97) 0.48 (0.014 to 0.96) −0.29 (−0.36 to −0.22) −0.14 (−0.28 to −0.00016) 0.05 24.65 (0 to 49.27)
AD 99th −1.13 (−3.55 to 1.28) 0.48 (0.014 to 0.96) −0.39 (−0.50 to −0.28) −0.19 (−0.38 to 0.0026) 0.053 16.61 (0 to 33.46)